Understanding how the Integrator complex controls gene expression
Probing the specificity and activity of the metazoan Integrator complex
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-10803613
This study looks at how a special protein complex helps control the process of making RNA, which is important for our cells to work properly, and it aims to understand how this complex can pause or change the way RNA is made in response to different signals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10803613 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Integrator complex in regulating gene expression by controlling the activity of RNA polymerase II, which is crucial for synthesizing RNA. The study focuses on how the Integrator complex can pause RNA polymerase II and influence its transition to productive RNA synthesis or termination. By examining the molecular mechanisms involved, the research aims to uncover how gene expression is finely tuned in response to various signals, which is essential for normal development and cellular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers that may be influenced by disruptions in gene regulation.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by the mechanisms studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for diseases related to gene expression, such as cancers and blood disorders.
How similar studies have performed: Previous research has shown success in understanding gene regulation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADELMAN, KAREN L — HARVARD MEDICAL SCHOOL
- Study coordinator: ADELMAN, KAREN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.