Understanding how the insular cortex influences motivation and behavior
Circuit architecture and dynamics of the insular cortex underlying motivational behaviors
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10729654
This study is looking at a part of the brain called the insular cortex to understand how different types of brain cells help shape our motivations and behaviors, which could help us learn more about what drives our feelings and actions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10729654 on ClinicalTrials.gov |
What this research studies
This research investigates the insular cortex, a brain region that plays a crucial role in integrating information about the body's internal state and external environment to influence motivation and behavior. By examining the activity of individual neurons within this area, the study aims to uncover how different types of neurons contribute to motivated behaviors. The researchers will utilize advanced techniques to classify neuronal types and their connections, as well as measure the effects of neuromodulators like dopamine on these circuits. This work could provide insights into the neural mechanisms that drive motivation and emotional responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing motivational or emotional challenges, particularly those with conditions like depression or anxiety disorders.
Not a fit: Patients with purely physical health issues unrelated to motivation or emotional regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to motivation and emotional regulation, such as depression or anxiety.
How similar studies have performed: Previous research has shown promising results in understanding the role of the insular cortex in motivation, suggesting that this approach could yield valuable insights.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAO, TIANYI — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: MAO, TIANYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.