Understanding how the immune system's proteasome affects inflammation in lung diseases
Official title: Molecular regulation of immunoproteasome assembly in inflammatory diseases
Funded at Ohio State University · NIH-10878768 · Data updated 2026-11-12
This study is looking at how a part of our immune system called the immunoproteasome affects inflammation during serious bacterial infections, like those that can cause acute respiratory distress syndrome (ARDS), to find new ways to help reduce harmful inflammation and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $576,618 |
| NIH project number | 5R01HL167846-02 |
| Project ID | NIH-10878768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients experiencing severe bacterial infections or those diagnosed with acute respiratory distress syndrome.
✕Less likely to help
Patients with non-infectious causes of respiratory distress or those not experiencing significant inflammation may not benefit from this research.
What this research studies
This research investigates the role of a specific part of the proteasome, known as the immunoproteasome, in the body's inflammatory response to severe bacterial infections, particularly in conditions like acute respiratory distress syndrome (ARDS). The study aims to uncover how the assembly of the immunoproteasome is regulated at a molecular level and how this process contributes to inflammation and tissue damage during infections. By exploring the potential to inhibit the immunoproteasome, the research seeks to identify new therapeutic targets that could help reduce harmful inflammation in patients suffering from severe infections. Patients may benefit from insights that could lead to novel treatments for ARDS and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve outcomes for patients with severe bacterial infections and ARDS.
How similar studies have gone: Previous research has shown promise in targeting the immunoproteasome for therapeutic purposes, indicating that this approach may lead to meaningful advancements in treatment.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zhao, Jing — Ohio State University
- Study coordinator: Zhao, Jing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.