Understanding how the immune system responds to severe infections
Mechanisms of Dysregulated Innate Immune Responses to Lethal Infections
['FUNDING_OTHER'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-10906102
This study is looking at how severe infections can mess up your immune system and cause problems like too much inflammation, and it's for anyone who wants to understand how we might find new ways to help people recover better from these tough infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-10906102 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the immune system can become dysregulated during severe infections, such as those caused by microbial toxins. The team aims to explore how certain proteins released by the body and toxins from pathogens can lead to harmful immune responses, including excessive inflammation and impaired immune function. By studying these interactions, the researchers hope to identify potential targets for new treatments that could help restore normal immune function in patients suffering from severe infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are experiencing severe infections, particularly those related to microbial pathogens like SARS-CoV-2.
Not a fit: Patients with mild infections or those who do not have a significant immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve immune responses in patients with severe infections, potentially saving lives.
How similar studies have performed: Previous research has successfully identified key mediators of immune responses in severe infections, suggesting that this approach has the potential for significant findings.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, HAICHAO — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: WANG, HAICHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.