Understanding how the immune system responds to Norovirus infection in humans.
Official title: Systems analysis of immune responses to Norovirus infection in a human challenge model.
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11056611 · Data updated 2026-11-12
This study is looking at how our immune system reacts when healthy adults are exposed to Norovirus, with the goal of understanding how we build immunity to it, which could help in creating better vaccines and treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $233,528 |
| NIH project number | 1R21AI183058-01A1 |
| Project ID | NIH-11056611 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are healthy adults aged 21 and older who are willing to participate in controlled infection trials.
✕Less likely to help
Patients with pre-existing health conditions or compromised immune systems may not benefit from this research.
What this research studies
This research investigates the immune responses to Norovirus infection by analyzing blood and stool samples from healthy adult volunteers who are intentionally infected with different strains of the virus. The study aims to profile the immune system's early responses using advanced technologies to better understand how the body develops immunity against Norovirus. By examining gene expression and immune cell profiles at various time points after infection, researchers hope to identify predictors of effective immunity. This could lead to insights that inform vaccine development and treatment strategies for Norovirus infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or treatments for Norovirus, significantly reducing the incidence of gastroenteritis caused by this virus.
How similar studies have gone: Previous research has shown promise in understanding immune responses to viral infections using similar high-throughput profiling techniques, but this specific approach to Norovirus is relatively novel.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Hagan, Thomas Lafayette — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Hagan, Thomas Lafayette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.