Understanding how the immune system responds to malaria in children
Official title: The Kinetics and Dynamics of Functional Immune Responses to Plasmodium falciparum Strains
Funded at Yale University · NIH-10825746 · Data updated 2026-11-12
This study is looking at how young children's immune systems fight off malaria in Sub-Saharan Africa, with the goal of finding ways to improve vaccines and treatments for kids under five.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI176818-01A1 |
| Project ID | NIH-10825746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under the age of five living in Sub-Saharan Africa who are at risk of malaria infection.
✕Less likely to help
Patients who are older than five years or those living outside of Sub-Saharan Africa may not benefit from this research.
What this research studies
This research investigates how children's immune systems respond to malaria caused by Plasmodium falciparum, particularly focusing on children under five years old in Sub-Saharan Africa. The study aims to identify specific immune responses and genetic factors that contribute to protection against malaria. By analyzing the dynamics of immune responses to malaria antigens over time, the research seeks to uncover critical information that could lead to better vaccines and treatments. The approach includes longitudinal studies that track immune responses and the genetic diversity of malaria strains.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for malaria, significantly reducing mortality rates in young children.
How similar studies have gone: Previous research has shown promise in understanding immune responses to malaria, but this study aims to provide novel insights into the specific mechanisms of immunity.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Hagadorn, Kelly — Yale University
- Study coordinator: Hagadorn, Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.