Understanding how the immune system responds to lung injury
Official title: The Establishment of Lung Resident Self-Antigen-Specific CD4+ Tregs Following Acute Tissue injury
Funded at Boston Children's Hospital · NIH-11033303 · Data updated 2026-11-12
This study is looking at how certain immune cells called Tregs react to lung injuries and whether they can help protect the lungs from getting worse, which could lead to new treatments for people with lung problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $194,740 |
| NIH project number | 1K08AI187736-01 |
| Project ID | NIH-11033303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute lung injuries or conditions that may lead to such injuries.
✕Less likely to help
Patients with chronic lung diseases that do not involve acute injury may not benefit from this research.
What this research studies
This research investigates how specific immune cells, known as Tregs, respond to acute lung injury and how they may help prevent further damage. By studying these cells in a controlled mouse model, the researchers aim to understand the mechanisms that allow the immune system to maintain tolerance to self-antigens during inflammation. The goal is to characterize the development of these Tregs and their potential long-term benefits in protecting lung tissue after injury. This could provide insights into new therapeutic strategies for patients with lung injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune system's ability to protect the lungs after injury.
How similar studies have gone: Other research has shown promising results in understanding immune responses to tissue injury, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shin, Daniel Seong-Joo — Boston Children's Hospital
- Study coordinator: Shin, Daniel Seong-Joo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.