Understanding how the immune system responds to latent cryptococcal infections in HIV patients
The adaptive host response to latent cryptococcosis
This study is looking at how the immune system helps keep a fungus called Cryptococcus neoformans under control in people with HIV, and it hopes to find ways to boost the immune response to prevent serious infections like meningitis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10974025 on NIH RePORTER |
What this research studies
This research investigates how the immune system controls latent infections caused by the fungus Cryptococcus neoformans, particularly in individuals with HIV. It aims to identify the immune responses that prevent the progression of these infections into severe conditions like cryptococcal meningitis. By using a specialized mouse model, the study will explore the role of specific immune cells and signaling pathways in managing these latent infections. The findings could lead to new therapies that enhance immune function in HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be at risk for cryptococcal infections.
Not a fit: Patients who do not have HIV or those who are not at risk for cryptococcal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent the progression of latent cryptococcal infections in HIV patients, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promise in understanding immune responses to fungal infections, but this specific approach to latent cryptococcosis in HIV patients is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Ding, Minna — University of Minnesota
- Study coordinator: Ding, Minna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.