Understanding how the immune system responds to influenza viruses
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES
This study is looking at how our immune system remembers and fights off the flu, starting with experiments in mice and then using that information to help understand how vaccines work for people, especially how past infections and vaccinations can shape our immune responses.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10842325 on NIH RePORTER |
What this research studies
This research aims to create a mathematical framework to understand how the immune system generates and maintains memory against influenza viruses. By first conducting experiments in mice, the researchers will validate their models before applying them to human vaccination data. The study will explore how previous immunity influences the effectiveness of vaccines and the durability of immune responses, particularly focusing on antibody responses to key viral components. Additionally, it will investigate how repeated exposure to influenza affects the immune system's T cell responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have received influenza vaccinations or have had previous influenza infections.
Not a fit: Patients who have not been vaccinated against influenza or have not had prior exposure to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved influenza vaccines that provide longer-lasting immunity and better protection against various strains of the virus.
How similar studies have performed: Previous research has shown promise in using mathematical models to understand immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Antia, Rustom Noshir — Emory University
- Study coordinator: Antia, Rustom Noshir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.