Understanding how the immune system responds to influenza vaccination
Official title: Computational Models of Adaptive Immunity to Influenza
Funded at University of Chicago · NIH-11017311 · Data updated 2026-11-12
This study is looking at how past experiences with the flu virus affect how well the Flublok vaccine works for adults, especially focusing on the immune system's response, and it’s designed for people who have had the vaccine before to help us understand what makes their immunity stronger and last longer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 23, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,225,986 |
| NIH project number | 1U01AI187063-01 |
| Project ID | NIH-11017311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have received the Flublok influenza vaccine multiple times.
✕Less likely to help
Patients who have not been vaccinated against influenza or those with certain immune deficiencies may not benefit from this research.
What this research studies
This research investigates the adaptive immune response to influenza vaccination, focusing on how prior exposure to the virus influences the strength and durability of the immune response. By enrolling adults who have received the Flublok vaccine multiple times, the study aims to identify factors that contribute to effective immune responses, including the roles of B and T cells. Participants will be monitored in a randomized trial to compare their immune responses with those of a control group. The research employs advanced statistical and mechanistic models to analyze how various factors shape immune responses over time.
Why it matters
Potential benefit: If successful, this research could lead to improved influenza vaccines that provide stronger and longer-lasting protection.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to vaccines, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Cobey, Sarah — University of Chicago
- Study coordinator: Cobey, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.