Understanding how the immune system responds to influenza
Regulation of the host immune response to influenza by the checkpoint receptor Tim3
This study is looking at how a part of your immune system called Tim3 helps your body fight off the flu, especially by focusing on a type of immune cell that plays a big role in battling infections, and it hopes to find better ways to treat people who get really sick from the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10846578 on NIH RePORTER |
What this research studies
This research investigates the role of a specific immune checkpoint receptor, Tim3, in regulating the immune response to influenza. By studying how Tim3 affects the activity of CD8+ T cells, which are crucial for fighting off influenza infections, the research aims to uncover new therapeutic strategies. The approach involves examining the interactions between dendritic cells and T cells in the lungs and lymph nodes to understand how to balance effective viral clearance with minimizing lung injury. This could lead to improved treatments for patients suffering from severe influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at high risk for severe influenza, such as those with compromised immune systems or underlying respiratory conditions.
Not a fit: Patients who are not affected by influenza or those who have already developed severe complications from the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response to influenza, potentially reducing morbidity and mortality associated with the virus.
How similar studies have performed: Previous research has shown promise in targeting immune checkpoint receptors to enhance immune responses, suggesting that this approach could be beneficial.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Cho, Josalyn L — University of Iowa
- Study coordinator: Cho, Josalyn L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.