Understanding how the immune system responds to HIV infection
Official title: Regulation and Manipulation of Innate Immunity During HIV Infection
Funded at University of Utah · NIH-11079626 · Data updated 2026-11-12
This study is looking at how our immune system fights HIV and is testing a specific gene to see if changing it can help boost the body's ability to respond to the virus, which could lead to better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $694,996 |
| NIH project number | 5R01AI181713-02 |
| Project ID | NIH-11079626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV or do not have risk factors for HIV may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the innate immune system detects and responds to HIV infection. It focuses on a specific gene, Core-Binding Factor Subunit Beta (CBFb), which plays a crucial role in regulating interferon signaling, a key component of the body's defense against viruses. By using advanced techniques like CRISPR-Cas9, the researchers aim to manipulate this gene to enhance the immune response against HIV. The findings could lead to new strategies for improving antiviral responses in patients with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the body's ability to fight HIV infection.
How similar studies have gone: Previous research has shown promise in manipulating immune responses to enhance antiviral activity, suggesting potential success for this approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Johnson, Jarrod Sean — University of Utah
- Study coordinator: Johnson, Jarrod Sean
Related research
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-
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-
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-
Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa
This project studies heart tissue changes in women with HIV in sub-Saharan Africa who are on antiretroviral therapy, to understand why they’re at higher risk for heart problems as they age.
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Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa
This grant studies heart tissue changes in women living with HIV in sub-Saharan Africa to understand why heart failure risk is higher in this group.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.