Understanding how the immune system responds to food proteins
CD4+ T cell response to food
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11020528
This study is looking at how certain immune cells in your body react to food proteins, which can help explain why some people develop conditions like celiac disease, and it aims to find ways to help those who struggle with food allergies or intolerances.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11020528 on ClinicalTrials.gov |
What this research studies
This research investigates how CD4+ T cells, a type of immune cell, interact with food proteins and why some individuals develop immune responses to these proteins, leading to conditions like celiac disease. The study employs advanced techniques such as peptide:MHCII tetramer-based cell enrichment and flow cytometry to analyze T cell responses in the gut. By examining how these immune cells proliferate and differentiate in response to food, the research aims to uncover the mechanisms that allow some people to tolerate food while others do not. The findings could lead to new insights into immune tolerance and potential treatments for food-related autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with celiac disease or those experiencing food intolerances and autoimmune responses.
Not a fit: Patients without any food-related autoimmune conditions or those who do not experience adverse reactions to food are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals with food-related autoimmune diseases, such as celiac disease.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to food, but this specific approach is novel and aims to fill existing knowledge gaps.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JENKINS, MARC KEVIN — UNIVERSITY OF MINNESOTA
- Study coordinator: JENKINS, MARC KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.