Understanding how the immune system responds to a fungal infection called coccidioidomycosis
Adaptive Immune Dysregulation in Disseminated Coccidioidomycosis
This study is looking at how the immune system, especially T cells, reacts to a fungal infection called coccidioidomycosis, with the hope of finding ways to improve treatments and prevention for patients dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11004679 on NIH RePORTER |
What this research studies
This research investigates how the immune system, particularly T cells, responds to the fungal infection known as disseminated coccidioidomycosis. The team aims to identify specific patterns and programs of T cell dysfunction that contribute to the severity of the disease. By utilizing modern techniques to discover key peptides and HLA alleles involved in immune response, the research seeks to enhance our understanding of how the body fights this infection. Patients may benefit from insights that could lead to improved treatments or preventive strategies against coccidioidomycosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with disseminated coccidioidomycosis or those at high risk for severe infections.
Not a fit: Patients with mild forms of coccidioidomycosis or those who do not have the disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and preventive measures for patients suffering from disseminated coccidioidomycosis.
How similar studies have performed: Previous research has shown success in understanding immune responses to fungal infections, but this specific approach to studying coccidioidomycosis is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Butte, Manish J — University of California Los Angeles
- Study coordinator: Butte, Manish J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.