Understanding how the immune system responds to a fungal infection called Coccidioides
Innate immune mechanisms of the host response to Coccidioides
This study is looking at how the immune system fights off a fungus called Coccidioides, which can cause serious infections, to help find better treatments for people who get really sick from it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11004670 on NIH RePORTER |
What this research studies
This research investigates the innate immune mechanisms that respond to Coccidioides, a pathogenic fungus responsible for thousands of infections in the U.S. each year. The focus is on understanding how the immune system recognizes and reacts to this fungus, particularly in patients who develop severe forms of the disease. Researchers will explore various aspects of the immune response, including how immune cells communicate and function, and the genetic factors that may influence these responses. By employing a collaborative approach, the study aims to uncover critical insights that could lead to improved treatments for those affected by severe infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with Coccidioides infections, particularly those experiencing severe symptoms.
Not a fit: Patients who have not been infected with Coccidioides or those with mild infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from severe fungal infections.
How similar studies have performed: Previous research on other invasive fungal pathogens has shown success in understanding immune responses, suggesting that this approach may yield valuable insights for Coccidioides as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hoffman, Harold M — University of California Los Angeles
- Study coordinator: Hoffman, Harold M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.