Understanding how the immune system remembers infections in humans
Unraveling the molecular mechanisms of innate immune memory in humans
This study is looking at how certain immune cells in our bodies can remember past infections, helping them fight off future ones better, and it’s for anyone interested in understanding how our immune system gets stronger over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11107380 on NIH RePORTER |
What this research studies
This research investigates how certain immune cells in humans can develop a memory of past infections, allowing them to respond more effectively to future threats. It focuses on innate immune cells, such as monocytes and macrophages, which have been found to exhibit long-term memory and enhanced responses after being exposed to pathogens. The study will explore the specific genetic and epigenetic changes that enable this 'trained immunity' and how these changes can be passed down from stem cells to their differentiated immune cells. By utilizing advanced techniques in genomics and immunology, the research aims to uncover the mechanisms behind this phenomenon.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diverse genetic backgrounds, particularly those who have received vaccinations like the Bacille Calmette-Guérin (BCG) vaccine.
Not a fit: Patients who have not been vaccinated or have underlying conditions that severely compromise their immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and therapies that enhance the immune response against infections.
How similar studies have performed: Previous research has shown promising results in understanding trained immunity, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Barreiro, Luis Bruno — University of Chicago
- Study coordinator: Barreiro, Luis Bruno
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.