Understanding how the immune system recognizes self and foreign cells
THE IMMUNE SELF-ASSOCIATED STORAGE ORGANELLE (SASO)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10999425
This study is looking at how our immune system tells the difference between our own healthy cells and harmful ones, like cancer cells, by exploring a new part of immune cells called the Self-Associated Storage Organelle (SASO), which could help improve cancer treatments and reduce unwanted immune reactions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10999425 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the immune system distinguishes between the body's own cells and foreign invaders, including cancer cells. It focuses on a newly identified organelle called the Self-Associated Storage Organelle (SASO) found in certain immune cells, which is believed to play a crucial role in maintaining this self-recognition. The study employs advanced imaging and analytical techniques alongside traditional methods to explore how SASO functions and how it can be leveraged to enhance anti-tumor immunity and reduce autoimmune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancer or autoimmune conditions who may benefit from enhanced immune responses.
Not a fit: Patients with conditions unrelated to immune function or those who are not currently experiencing cancer or autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve the immune system's ability to fight cancer while minimizing harmful autoimmune reactions.
How similar studies have performed: Other research has shown promise in understanding immune mechanisms, but the specific focus on the SASO is a novel approach that has not been extensively tested.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRUMMEL, MATTHEW F — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KRUMMEL, MATTHEW F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.