Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
This study is looking at how our immune system fights against tuberculosis and how it might be affected by COVID-19, with the goal of finding better ways to improve vaccines for people at risk of TB.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11179083 on NIH RePORTER |
What this research studies
This research investigates the immune responses that protect against Mycobacterium tuberculosis (Mtb) infection by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The study aims to identify key immune mechanisms and potential targets for improving tuberculosis vaccine strategies. Additionally, it will explore the effects of co-infection with SARS-CoV-2 on the immune system of participants with varying levels of Mtb infection. Through this comprehensive approach, the research seeks to enhance our understanding of tuberculosis immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk of tuberculosis infection or have been diagnosed with tuberculosis.
Not a fit: Patients who are not at risk for tuberculosis or have no history of exposure to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this study aims to explore novel aspects related to co-infection with SARS-CoV-2.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Urdahl, Kevin — Seattle Children's Hospital
- Study coordinator: Urdahl, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.