Understanding how the immune system protects against tuberculosis
Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB)
This study is looking at how our immune system fights against tuberculosis and how it might be affected by COVID-19, with the goal of finding better ways to improve tuberculosis vaccines, and it may involve patients providing samples or sharing information about their immune responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11179082 on NIH RePORTER |
What this research studies
This research investigates the immune responses that protect against Mycobacterium tuberculosis (Mtb) infection by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The study aims to identify key immune mechanisms and potential immunologic targets that could enhance tuberculosis vaccine strategies. Additionally, it will explore the effects of co-infection with SARS-CoV-2 on the immune system, providing insights into how these infections interact. Patients may be involved in providing samples or participating in assessments related to their immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a history of tuberculosis infection or those at high risk for tuberculosis.
Not a fit: Patients who are not at risk for tuberculosis or do not have a history of the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach is particularly novel in its focus on co-infection with SARS-CoV-2.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Urdahl, Kevin — Seattle Children's Hospital
- Study coordinator: Urdahl, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.