Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
This study is looking at how our immune system fights tuberculosis and aims to find ways to make vaccines better, especially for people who might also have other infections like HIV. If you're a patient, you might have the chance to help us learn more about your immune responses to improve treatment and prevention for tuberculosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11179081 on NIH RePORTER |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic responses in small animals, non-human primates, and humans. The team aims to identify key immunologic targets that could enhance tuberculosis vaccine strategies. Additionally, the research will explore how infections like HIV and other mycobacteria affect immune responses to tuberculosis. Patients may be involved in studies that assess their immune responses to better understand how to improve treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates include individuals at risk for tuberculosis, especially those with HIV or other immune-compromising conditions.
Not a fit: Patients who are not at risk for tuberculosis or do not have any immune-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for tuberculosis, particularly for those with compromised immune systems.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide deeper insights and potentially novel strategies.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Urdahl, Kevin — Seattle Children's Hospital
- Study coordinator: Urdahl, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.