Understanding how the immune system protects against tuberculosis
Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB)
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11158537
This study is looking at how our immune system fights tuberculosis and aims to find ways to improve vaccines for it, especially for people who might also have other infections like HIV; if you're interested, you can help by sharing samples or joining in on the research.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11158537 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The team aims to identify key immunologic targets that could enhance tuberculosis vaccine strategies. Additionally, the research will explore how infections like HIV and other mycobacteria affect immune responses to tuberculosis. Patients may contribute to this research by providing samples or participating in studies that assess their immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a history of tuberculosis exposure or those living with HIV, as their immune responses are particularly relevant to the study.
Not a fit: Patients who have no history of tuberculosis exposure or related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide deeper insights and is considered innovative.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLER, RHEA — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: COLER, RHEA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus