Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10930674
This study is looking at how our immune system fights off tuberculosis and how it might be affected by other infections like COVID-19, to help improve vaccines for people at risk of getting TB.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10930674 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses that protect against Mycobacterium tuberculosis (Mtb) infection by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The team will conduct detailed immunologic analyses to identify key immune mechanisms and potential targets for improving tuberculosis vaccine strategies. Additionally, the study will explore the effects of co-infection with SARS-CoV2 on these immune responses, providing insights into how multiple infections may influence immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for tuberculosis infection or those with a history of tuberculosis exposure.
Not a fit: Patients who are not at risk for tuberculosis or who have already been effectively treated for the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach is particularly focused on the interplay with SARS-CoV2, making it a novel investigation.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: URDAHL, KEVIN — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: URDAHL, KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.