Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
This study is looking at how our immune system fights tuberculosis and how different infections, like HIV, can change that response, with the goal of finding better ways to protect people from TB through vaccines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10930673 on NIH RePORTER |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The team aims to identify key immunologic targets that could enhance tuberculosis vaccine strategies. Additionally, the research will explore how infections like HIV and non-tuberculous mycobacteria affect immune responses to Mtb and TB vaccines. Through this comprehensive approach, the study seeks to improve our understanding of tuberculosis immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for tuberculosis infection or those who have been diagnosed with tuberculosis.
Not a fit: Patients who are not at risk for tuberculosis or who have already received effective treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective tuberculosis vaccines, ultimately reducing the incidence of this disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide deeper insights and potentially novel strategies.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Urdahl, Kevin — Seattle Children's Hospital
- Study coordinator: Urdahl, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.