Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
This study is looking at how our immune system fights tuberculosis and aims to find ways to improve vaccines for it, especially for people who might also have other infections like HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10925119 on NIH RePORTER |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic immune reactions in small animals, non-human primates, and humans. The team aims to identify key immunologic targets that could enhance tuberculosis vaccine strategies. Additionally, the research will explore how infections like HIV and non-tuberculous mycobacteria affect immune responses to tuberculosis and how Mtb evades these immune defenses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for tuberculosis infection or those with compromised immune systems, such as HIV-positive patients.
Not a fit: Patients who are not at risk for tuberculosis or who have already been effectively vaccinated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide deeper insights and is considered innovative.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Fortune, Sarah — Harvard School of Public Health
- Study coordinator: Fortune, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.