Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
This study is looking at how our immune system fights tuberculosis and how it might be affected by COVID-19, so we can find better ways to protect people from TB, whether they are healthy or dealing with an infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10721327 on NIH RePORTER |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic responses in small animals, non-human primates, and humans. The team of researchers will conduct detailed immunologic analyses to identify key immune mechanisms and potential targets for improving tuberculosis vaccine strategies. Additionally, the study will explore the effects of co-infection with SARS-CoV2 on the immune system of participants with varying stages of Mtb infection.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with varying stages of Mycobacterium tuberculosis infection, as well as those co-infected with SARS-CoV2.
Not a fit: Patients who are not infected with Mycobacterium tuberculosis or do not have a history of co-infection with SARS-CoV2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach is particularly novel in its focus on co-infection with SARS-CoV2.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Urdahl, Kevin — Seattle Children's Hospital
- Study coordinator: Urdahl, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.