Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - DMID
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10691838
This study is looking at how our immune system fights tuberculosis and how it might be affected by COVID-19, with the goal of finding better ways to create vaccines for people at different stages of tuberculosis infection.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10691838 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic responses in small animals, non-human primates, and humans. The team will conduct detailed immunologic analyses to identify key immune mechanisms and potential targets for improving tuberculosis vaccine strategies. Additionally, the study will explore the effects of co-infection with SARS-CoV2 on innate immunity in individuals with varying stages of Mtb infection.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a history of tuberculosis infection or those at risk of exposure to Mtb.
Not a fit: Patients who are not at risk for tuberculosis or have no history of infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection against the disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide novel insights into co-infection effects and vaccine development.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: URDAHL, KEVIN — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: URDAHL, KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.