Understanding how the immune system protects against tuberculosis
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10691837
This study is looking at how our immune system fights tuberculosis and how different infections, like HIV, can change that response, with the goal of finding better ways to protect people from TB, including those who might participate in the research.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10691837 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses necessary for protection against Mycobacterium tuberculosis (Mtb) by analyzing tissue-specific and systemic responses in small animals, non-human primates, and humans. The team aims to identify key immune mechanisms and targets that could enhance tuberculosis vaccine strategies. Additionally, the research will explore how infections like HIV and other mycobacteria affect immune responses to tuberculosis. Patients may be involved in studies that assess their immune responses and how they relate to tuberculosis protection.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a history of tuberculosis exposure or those living with HIV.
Not a fit: Patients who are not at risk for tuberculosis or do not have any immune-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis vaccines and better protection for individuals at risk of infection.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this approach aims to provide deeper insights and is considered innovative.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: URDAHL, KEVIN — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: URDAHL, KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus