Understanding how the immune system processes and presents influenza antigens
Defining the four major routes of MHC class II antigen processing and presentation with influenza antigens
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11097279
This study is looking at how certain immune cells called CD4+ T cells get activated by the flu virus, which could help us create better treatments and vaccines for infections and cancer that might help patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11097279 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which CD4+ T cells, crucial for immune responses, are activated by antigens from influenza. It focuses on how these antigens are processed and presented by antigen-presenting cells through various pathways, including classical and non-classical routes. By examining these processes in detail, the research aims to enhance our understanding of immune activation, which could lead to improved therapies for infections and cancers. Patients may benefit from insights that could inform new immunotherapies or vaccines.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases, cancer, or those at risk of influenza infections.
Not a fit: Patients with conditions unrelated to immune response or those not affected by influenza or cancer may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for infectious diseases and cancers.
How similar studies have performed: Previous research has shown success in understanding immune mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EISENLOHR, LAURENCE CRANE — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: EISENLOHR, LAURENCE CRANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer, anti-cancer immunotherapy, anticancer immunotherapy