Understanding how the immune system processes and presents influenza antigens
Official title: Defining the four major routes of MHC class II antigen processing and presentation with influenza antigens
Funded at Children's Hosp of Philadelphia · NIH-11097279 · Data updated 2026-11-12
This study is looking at how certain immune cells called CD4+ T cells get activated by the flu virus, which could help us create better treatments and vaccines for infections and cancer that might help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $598,313 |
| NIH project number | 5R01AI180250-02 |
| Project ID | NIH-11097279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases, cancer, or those at risk of influenza infections.
✕Less likely to help
Patients with conditions unrelated to immune response or those not affected by influenza or cancer may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which CD4+ T cells, crucial for immune responses, are activated by antigens from influenza. It focuses on how these antigens are processed and presented by antigen-presenting cells through various pathways, including classical and non-classical routes. By examining these processes in detail, the research aims to enhance our understanding of immune activation, which could lead to improved therapies for infections and cancers. Patients may benefit from insights that could inform new immunotherapies or vaccines.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for infectious diseases and cancers.
How similar studies have gone: Previous research has shown success in understanding immune mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Eisenlohr, Laurence Crane — Children's Hosp of Philadelphia
- Study coordinator: Eisenlohr, Laurence Crane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.