Understanding how the immune system kills gonorrhea bacteria
Official title: Defining mechanisms of complement-mediated killing of Neisseria gonorrhoeae
Funded at University of Virginia · NIH-11061195 · Data updated 2026-11-12
This study is looking at how our immune system fights the bacteria that cause gonorrhea, with a special focus on a part of the immune response called the complement system, to find better ways to treat or prevent this infection, especially as antibiotics become less effective.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AI179038-02 |
| Project ID | NIH-11061195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or currently infected with gonorrhea, particularly those experiencing complications from the infection.
✕Less likely to help
Patients who are not at risk for gonorrhea or those who have already been effectively treated for the infection may not benefit from this research.
What this research studies
This research investigates the immune mechanisms that help the body fight against Neisseria gonorrhoeae, the bacteria responsible for gonorrhea. It focuses on the role of the complement system, a part of the immune response that enhances the ability of immune cells to eliminate bacteria. By studying how this system works, especially in the presence of antibodies, the research aims to uncover new insights into how to better combat gonorrhea, particularly in light of rising antibiotic resistance. The findings could lead to improved treatments or vaccines for this common and serious infection.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments or vaccines for gonorrhea, reducing its prevalence and associated health complications.
How similar studies have gone: Previous research has shown that understanding immune mechanisms can lead to breakthroughs in treating bacterial infections, suggesting potential success for this approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Lamb, Evan R — University of Virginia
- Study coordinator: Lamb, Evan R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.