Understanding how the immune system fights viral infections in asthma patients
Role of immunoproteasome in airway viral infection
['FUNDING_R01'] · NATIONAL JEWISH HEALTH · NIH-10827949
This study is looking at how a part of the immune system works during colds caused by rhinovirus in people with asthma, especially those with type 2 inflammation, to find better ways to help clear the virus and ease asthma symptoms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NATIONAL JEWISH HEALTH (nih funded) |
| Locations | 1 site (DENVER, UNITED STATES) |
| Trial ID | NIH-10827949 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific immune component called immunoproteasome during rhinovirus infections in patients with asthma characterized by type 2 inflammation. The study aims to uncover how this immune mechanism can be regulated to improve the clearance of the virus from airway cells, which is crucial since rhinovirus infections can worsen asthma symptoms. By examining airway epithelial cells from patients and using animal models, the researchers will explore how the presence of type 2 inflammation affects the immune response to viral infections. The ultimate goal is to identify new therapeutic strategies to enhance viral clearance and reduce inflammation in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma, particularly those experiencing type 2 inflammation and frequent rhinovirus infections.
Not a fit: Patients without asthma or those whose condition is not characterized by type 2 inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of viral infections in asthma patients, potentially reducing exacerbations and improving quality of life.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
DENVER, UNITED STATES
- NATIONAL JEWISH HEALTH — DENVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHU, HONG W — NATIONAL JEWISH HEALTH
- Study coordinator: CHU, HONG W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.