Understanding how the immune system fights off certain viral infections
The role of pattern recognition and autophagy in innate anti-bunyaviral immunity
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10686406
This study is looking at how our immune system fights off viruses carried by insects, using fruit flies to learn more about how our cells can get rid of these viruses, which could help develop new treatments for people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10686406 on ClinicalTrials.gov |
What this research studies
This research investigates the innate immune response to arthropod-borne viral infections, focusing on how specific receptors in the immune system recognize and respond to these viruses. By using the fruit fly Drosophila as a model organism, the study explores the mechanisms of antiviral autophagy, a process that helps cells eliminate viral infections. The researchers aim to identify which pathways are activated in different types of cells during viral infections, which could lead to new antiviral therapies for humans. The findings may help bridge the gap in our understanding of how the immune system can effectively combat these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for infections caused by arthropod-borne viruses, such as those living in endemic areas or with compromised immune systems.
Not a fit: Patients who are not at risk for arthropod-borne viral infections or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments that enhance the body's natural immune response.
How similar studies have performed: Previous research has shown promising results in using similar immune response mechanisms to combat viral infections, indicating that this approach has potential.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHERRY, SARA — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: CHERRY, SARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.