Understanding how the immune system fights gammaherpesviruses in AIDS patients
Dissecting immune surveillance to gammaherpesviruses
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-10894834
This study is looking at how the immune system responds to certain viruses in people with AIDS, focusing on a type of immune cell called CD8 T cells, to find ways to help boost their immune defenses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10894834 on ClinicalTrials.gov |
What this research studies
This research investigates the immune response to gammaherpesviruses, such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, in patients with AIDS. It focuses on the role of CD8 T cells, which are crucial for controlling these viral infections. By studying the mechanisms that lead to immune deficiency in AIDS patients, the research aims to identify ways to restore effective immune surveillance. The approach includes using a rodent model to explore the function of a specific transcription repressor, Zbtb20, in immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with AIDS who are experiencing complications related to gammaherpesvirus infections.
Not a fit: Patients who do not have AIDS or those who are not infected with gammaherpesviruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in AIDS patients, potentially reducing the severity of gammaherpesvirus-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to similar viral infections, indicating that this approach has potential for success.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: USHERWOOD, EDWARD J — DARTMOUTH COLLEGE
- Study coordinator: USHERWOOD, EDWARD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus