Understanding how the immune system fights fungal infections
Trained immunity and the regulation of anti-fungal defense
This study is looking at how the immune system fights off certain fungal infections that can be dangerous for people with weakened immune systems, like those who have had organ transplants or cancer treatments, to find better ways to help them stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11023131 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms that protect against fungal infections, specifically focusing on Aspergillus fumigatus and Cryptococcus neoformans, which pose significant risks to immunosuppressed patients. The study aims to explore how previous infections influence the response of lung macrophages, which are crucial for defending against these pathogens. By examining the different types of macrophages and their training to respond to infections, the research seeks to identify new immune-based treatments that could enhance patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunosuppressed individuals, such as those with HIV/AIDS or undergoing chemotherapy, who are at high risk for fungal infections.
Not a fit: Patients with robust immune systems or those not at risk for fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve the immune response to fungal infections in vulnerable patients.
How similar studies have performed: Previous research has shown promise in understanding immune responses to fungal infections, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Rivera, Amariliz — Rutgers Biomedical and Health Sciences
- Study coordinator: Rivera, Amariliz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.