Understanding how the immune system fights Cryptosporidium infections
Immunity to Cryptosporidium
This study is looking at how the immune system, especially T cells, fights off a parasite called Cryptosporidium that causes bad diarrhea in young kids, with the hope of creating a vaccine to help protect them better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11131976 on NIH RePORTER |
What this research studies
This research investigates how the immune system, particularly T cells, responds to Cryptosporidium, a parasite that causes severe diarrhea in young children. The study aims to identify the types of immune responses necessary for effective vaccination against this parasite. By utilizing advanced genetic tools and mouse models, researchers will explore the roles of specific immune pathways and factors in controlling the infection. The ultimate goal is to develop a vaccine that can provide lasting protection for vulnerable populations, especially children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old, particularly those with weakened immune systems or a history of severe gastrointestinal infections.
Not a fit: Patients who are adults or those without a history of Cryptosporidium infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of an effective vaccine against Cryptosporidium, significantly reducing illness in young children.
How similar studies have performed: Previous research has shown promise in understanding immune responses to similar parasitic infections, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hunter, Christopher a — University of Pennsylvania
- Study coordinator: Hunter, Christopher a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.