Understanding how the immune system fights Candida infections
C5a/C5ar1 signaling in protective immunity during invasive candidiasis
This study is looking at how certain parts of the immune system help fight off the fungus Candida albicans, which can cause serious infections in people with weakened immune systems, like those with cancer, to find better ways to treat these infections and improve patient care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10659261 on NIH RePORTER |
What this research studies
This research investigates the immune responses to the fungus Candida albicans, which causes serious infections in many patients, particularly those with weakened immune systems like cancer patients. The study focuses on the roles of specific immune components, C3 and C5, in controlling fungal growth and improving patient outcomes. By exploring how these components work together to enhance the body's ability to fight infections, the research aims to identify new strategies for antifungal therapies. Patients may benefit from insights that could lead to better treatment options and improved survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer patients undergoing hematopoietic cell transplants who are at risk for systemic candidiasis.
Not a fit: Patients with non-fungal infections or those not undergoing immunosuppressive treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved antifungal therapies and better outcomes for patients suffering from systemic candidiasis.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to fungal infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Desai, Jigarkumar V — Hackensack University Medical Center
- Study coordinator: Desai, Jigarkumar V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.