Understanding how the immune system fights Aspergillus fumigatus infections
IL-1 signaling in defense against Aspergillus fumigatus infection
This study is looking at how certain immune cells work together to fight off a fungus that can cause serious lung infections in people with weakened immune systems, with the hope of finding better ways to treat these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892923 on NIH RePORTER |
What this research studies
This research investigates the role of IL-1 signaling in the immune response to Aspergillus fumigatus, a fungus that can cause severe lung infections in immunocompromised patients. The study aims to identify how different immune cells, particularly neutrophils and monocytes, work together with lung structural cells to combat this infection. By examining the production of key immune signaling molecules, the research seeks to uncover new insights into how the body defends itself against fungal infections, which could lead to improved treatments. The methodology involves using mouse models to explore the cellular interactions and immune responses during infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals who are at risk of developing invasive aspergillosis.
Not a fit: Patients with healthy immune systems or those not at risk for fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against Aspergillus fumigatus infections, potentially saving lives.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to fungal infections, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mills, Kathleen — Weill Medical Coll of Cornell Univ
- Study coordinator: Mills, Kathleen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.