Understanding how the immune system develops in infants at risk for allergies
Official title: Data Management and Bioinformatics
Funded at University of Rochester · NIH-11075807 · Data updated 2026-11-12
This study is looking at how babies' immune systems grow in their first year, especially for those who might be more likely to develop allergies, and it aims to find out what helps protect them from these allergies by comparing different groups of babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 7, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $124,617 |
| NIH project number | 5U19AI175113-03 |
| Project ID | NIH-11075807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants under 12 months old, particularly those with a family history of allergies or those living in urban environments.
✕Less likely to help
Patients who are older than 11 months or do not have any risk factors for allergic diseases may not benefit from this research.
What this research studies
This research investigates the development of the immune system in infants during their first year of life, focusing on those at high risk for allergic diseases compared to those at low risk. It emphasizes the role of mucosal immunity, where allergens are first encountered, and the microbiome's influence on immune responses. The study collects extensive data from various biological samples, including blood and stool, to analyze immune markers and responses over time. By comparing different populations, including urban infants and those from traditional farming communities, the research aims to uncover protective factors against allergies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for allergic diseases in infants.
How similar studies have gone: Previous research has shown success in understanding immune development and its relation to allergies, making this approach both relevant and promising.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Thakar, Juilee — University of Rochester
- Study coordinator: Thakar, Juilee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.