Understanding how the immune system detects double-stranded DNA in cells.
Mechanistic Studies of cytosolic double-stranded DNA sensing pathways.
This study is looking at how our body's immune system detects and reacts to double-stranded DNA that shouldn't be in our cells, which can signal problems like infections or cell damage, and it aims to help us understand how these processes work so we can learn more about diseases that happen when things go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11099399 on NIH RePORTER |
What this research studies
This research investigates how the innate immune system identifies and responds to double-stranded DNA (dsDNA) found in the cytosol of cells, which can indicate serious issues like infections or damage. By exploring the mechanisms behind dsDNA sensing pathways, the study aims to uncover how these pathways are activated and regulated at a molecular level. The research employs advanced techniques such as X-ray crystallography, biochemical assays, and electron microscopy to analyze the interactions and functions of immune sensors. The findings could provide insights into how malfunctions in these pathways contribute to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions linked to immune system malfunctions.
Not a fit: Patients with conditions unrelated to immune system responses or those not exhibiting symptoms related to dsDNA sensing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases related to immune system dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to DNA, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Sohn, Jungsan — Johns Hopkins University
- Study coordinator: Sohn, Jungsan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.