Understanding how the immune system controls hepatitis B in people with HIV.
HBV-specific T cell immunity in HBV/HIV coinfection
This study is looking at how the immune system responds to hepatitis B in people who also have HIV, with the goal of finding better treatments to help them manage both infections and improve their health.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10900779 on NIH RePORTER |
What this research studies
This research investigates the immune response to hepatitis B virus (HBV) in individuals who are also living with HIV. It aims to understand the biology of HBV and the role of specific immune cells, particularly CD4 T cells, in controlling HBV infection. The study will explore novel antiviral and immunotherapy approaches to improve treatment outcomes for those with HBV/HIV coinfection. By focusing on the mechanisms that lead to a functional cure of HBV, the research seeks to enhance current therapies and address the high mortality rates associated with this coinfection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are living with both HIV and hepatitis B virus.
Not a fit: Patients who do not have HIV or hepatitis B virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially a cure for hepatitis B in patients who are also living with HIV.
How similar studies have performed: While there has been limited research specifically on HBV/HIV coinfection, studies on HBV therapies have shown promise, indicating potential for success in this area.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Vinikoor, Michael Jeffrey — University of Alabama at Birmingham
- Study coordinator: Vinikoor, Michael Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.