Understanding how the immune system controls Candida infections in the gut
Immune Regulation of Candida GI Tract Colonization
['FUNDING_P01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11061777
This study is looking at how the immune system helps keep harmful fungi, like Candida, from causing infections in people who are more at risk, such as premature babies and organ transplant patients, so we can find better ways to protect them.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11061777 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system regulates the colonization of Candida species in the gastrointestinal tract, particularly in vulnerable populations such as premature infants and organ transplant recipients. By studying the interactions between Candida and the gut microbiota, the researchers aim to identify the immune mechanisms that prevent these fungi from entering the bloodstream and causing severe infections. The approach includes in vivo experiments to assess the role of specific immune pathways and cellular responses in controlling Candida colonization. This research could lead to better strategies for preventing fungal infections in at-risk patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include premature neonates, patients with hematologic malignancies, and organ transplant recipients.
Not a fit: Patients without compromised immune systems or those not at risk for Candida infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for serious fungal infections in high-risk patients.
How similar studies have performed: Previous research has shown that understanding immune responses to fungal infections can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOHL, TOBIAS M — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: HOHL, TOBIAS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.