Understanding how the immune system controls Candida infections in the gut
Official title: Immune Regulation of Candida GI Tract Colonization
Funded at Sloan-Kettering Inst Can Research · NIH-11061777 · Data updated 2026-11-12
This study is looking at how the immune system helps keep harmful fungi, like Candida, from causing infections in people who are more at risk, such as premature babies and organ transplant patients, so we can find better ways to protect them.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $560,028 |
| NIH project number | 5P01AI179406-02 |
| Project ID | NIH-11061777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include premature neonates, patients with hematologic malignancies, and organ transplant recipients.
✕Less likely to help
Patients without compromised immune systems or those not at risk for Candida infections may not benefit from this research.
What this research studies
This research investigates how the immune system regulates the colonization of Candida species in the gastrointestinal tract, particularly in vulnerable populations such as premature infants and organ transplant recipients. By studying the interactions between Candida and the gut microbiota, the researchers aim to identify the immune mechanisms that prevent these fungi from entering the bloodstream and causing severe infections. The approach includes in vivo experiments to assess the role of specific immune pathways and cellular responses in controlling Candida colonization. This research could lead to better strategies for preventing fungal infections in at-risk patients.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for serious fungal infections in high-risk patients.
How similar studies have gone: Previous research has shown that understanding immune responses to fungal infections can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hohl, Tobias M — Sloan-Kettering Inst Can Research
- Study coordinator: Hohl, Tobias M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.