Understanding how the immune system contributes to high blood pressure
Mechanisms of Immune Activation in Hypertension
This study is exploring how the immune system might contribute to high blood pressure by looking at certain immune cells and proteins, and it invites patients to help by providing blood samples to better understand these processes and find new ways to treat hypertension.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10763005 on NIH RePORTER |
What this research studies
This research investigates the role of the immune system in causing high blood pressure, focusing on how certain immune cells, particularly dendritic cells, become activated. The study looks at a specific process involving the formation of isolevuglandins, which are modified proteins that can trigger immune responses. By examining these mechanisms in both animal models and human samples, the research aims to identify potential new targets for treating hypertension. Patients may be involved in providing blood samples to help understand these immune processes better.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults with hypertension or those at risk of developing high blood pressure.
Not a fit: Patients with low blood pressure or those not affected by hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for high blood pressure by targeting immune system mechanisms.
How similar studies have performed: Previous research has shown that immune system involvement in hypertension is a promising area, indicating potential for breakthroughs in treatment.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Harrison, David G — Vanderbilt University Medical Center
- Study coordinator: Harrison, David G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.