Understanding how the immune system can prevent severe damage from schistosomiasis
STING-Dependent Pathways Restraining Severe Schistosome Immunopathology
This study is looking at how our immune system reacts to schistosomiasis, a disease caused by parasitic worms, to find ways to help people avoid serious inflammation and damage from the parasite's eggs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11017692 on NIH RePORTER |
What this research studies
This research investigates the immune response to schistosomiasis, a disease caused by parasitic worms. It focuses on how certain immune pathways, particularly those involving a molecule called STING, can protect the body from severe inflammation and tissue damage caused by the parasite's eggs. By studying different mouse models, the researchers aim to uncover mechanisms that could lead to better treatments for patients suffering from this disease. The approach includes examining immune cell responses and the role of specific receptors in managing inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schistosomiasis, particularly those experiencing severe symptoms.
Not a fit: Patients who do not have schistosomiasis or those with mild cases that do not require intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce severe complications from schistosomiasis, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to parasitic infections, suggesting that this approach could yield valuable insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Kalantari, Parisa — Pennsylvania State University, the
- Study coordinator: Kalantari, Parisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.