Understanding how the immune system can be regulated to fight persistent viral infections
Regulation of host immunity to impact virus persistence
This study is looking at how some viruses can hide from our immune system and stick around for a long time, and it’s specifically testing how a protein called SK2 affects the immune response in mice, with hopes that the results will help develop better treatments for people dealing with stubborn viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11103151 on NIH RePORTER |
What this research studies
This research investigates how certain viruses can evade the immune system and establish long-lasting infections. Using a mouse model infected with a specific strain of lymphocytic choriomeningitis virus, the study focuses on the role of sphingosine kinase 2 (SK2) in regulating immune responses. By examining how SK2 affects T cell activity, the researchers aim to identify potential therapeutic strategies to enhance the immune response against chronic viral infections. The findings could lead to new treatments that help the body clear persistent infections more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic viral infections or those at risk of developing such infections.
Not a fit: Patients with acute viral infections or those who do not have a history of chronic viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the immune response against chronic viral infections, potentially reducing morbidity and mortality associated with these conditions.
How similar studies have performed: Previous research has shown promising results in understanding immune regulation in chronic infections, suggesting that this approach could yield significant insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Hahm, Bumsuk — University of Missouri-Columbia
- Study coordinator: Hahm, Bumsuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.