Understanding how the immune system can be adjusted to fight a common lung infection.
Official title: Tuning complement-mediated immunity in aspergillosis: a systems medicine approach
Funded at University of Florida · NIH-10996181 · Data updated 2026-11-12
This study is looking at how a part of the immune system can help fight a serious fungal infection called invasive aspergillosis, especially in people with weakened immune systems, and aims to find better treatments that can reduce lung damage while still protecting against the infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | December 7, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $116,844 |
| NIH project number | 5K25AI175668-02 |
| Project ID | NIH-10996181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are immunocompromised patients at risk for invasive aspergillosis.
✕Less likely to help
Patients with non-fungal lung infections or those not immunocompromised may not benefit from this research.
What this research studies
This research investigates the role of the immune system's complement pathway in invasive aspergillosis, a serious fungal infection affecting immunocompromised patients. It aims to understand how complement activation can both protect against infections and contribute to lung injury and inflammation. By using mathematical modeling, the study seeks to design effective therapies that can intervene in the harmful interactions between pulmonary hemorrhage and complement activation. This approach may lead to new treatment strategies for managing pulmonary aspergillosis.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve outcomes for patients suffering from invasive aspergillosis.
How similar studies have gone: Previous research has shown promise in using complement inhibitors for treating similar conditions, indicating potential for success in this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Sordo Vieira, Luis Alfonso — University of Florida
- Study coordinator: Sordo Vieira, Luis Alfonso
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.