Understanding how the immune system and genetics affect tissue healing in humans and mice
Immune and genetic controls of tissue regeneration in mice and humans
This study is looking at how our immune system and genes help our bodies heal better, with the hope of finding ways to improve healing for people by understanding how tissue can regenerate without scars.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10906670 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind tissue regeneration, focusing on how certain immune responses and genetic factors can lead to better healing outcomes. By studying both mice and humans, the researchers aim to identify the molecular pathways that allow for complete tissue regeneration without scarring. The approach includes using advanced techniques like single-cell RNA sequencing to analyze the healing process and the effects of specific treatments, such as topical imiquimod, on tissue repair. The ultimate goal is to translate these findings into improved healing strategies for human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with skin injuries or conditions that result in scarring, such as diabetic foot ulcers or bed sores.
Not a fit: Patients with conditions that do not involve tissue regeneration or scarring may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance tissue healing and reduce scarring in patients.
How similar studies have performed: Previous studies have shown promising results in enhancing tissue regeneration in animal models, indicating potential for success in this area of research.
Where this research is happening
Philadelphia, United States
- Philadelphia VA Medical Center — Philadelphia, United States (Active)
Researchers
- Principal investigator: Leung, Thomas H. — Philadelphia VA Medical Center
- Study coordinator: Leung, Thomas H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.