Understanding how the immune system affects pain remission and relapse
Neuroimmune interactions regulating the balance between remission and relapse of pain
This study is looking at how the immune system affects pain and why some people feel pain again after getting better, with the goal of finding new ways to help those with ongoing pain and reduce the need for opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11058398 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the immune system and pain management, particularly focusing on how these interactions can lead to either remission or relapse of pain. By using a novel mouse model, researchers will explore the mechanisms that allow some patients to experience a return of pain after a period of relief. The study aims to identify new therapeutic strategies that could prevent the transition from acute to chronic pain and reduce reliance on opioids for pain management. The findings could lead to better treatments for individuals suffering from persistent pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing persistent pain, particularly those who have had episodes of pain relapse after periods of remission.
Not a fit: Patients with acute pain that does not transition to chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage pain and prevent its recurrence, improving the quality of life for many patients.
How similar studies have performed: Other research has shown promise in understanding the role of immune signaling in pain management, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Laumet, Geoffroy O — Michigan State University
- Study coordinator: Laumet, Geoffroy O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.