Understanding how the immune system affects organ transplant success
Official title: Innate Allorecognition in Clinical Organ Transplantation
Funded at University of Pittsburgh at Pittsburgh · NIH-10982471 · Data updated 2026-11-12
This study is looking at how the immune system can affect the success of kidney transplants, especially by focusing on certain immune cells and how they react to the transplanted organ, to help find out why some transplants fail and how to improve them for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | December 20, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $698,177 |
| NIH project number | 5R01AI172973-03 |
| Project ID | NIH-10982471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are kidney transplant recipients who have undergone transplantation and are experiencing or at risk for long-term graft loss.
✕Less likely to help
Patients who have not received a kidney transplant or those with other types of organ transplants may not benefit from this research.
What this research studies
This research investigates how the immune system's innate response can lead to long-term organ transplant failure, particularly focusing on kidney transplants. It examines the role of specific immune cells, called monocytes, and their activation by molecules from the transplanted organ. By analyzing donor and recipient pairs, the study aims to identify genetic mismatches that may increase the risk of graft loss. The research employs advanced techniques to assess the behavior of these immune cells and their impact on transplant outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing long-term organ transplant rejection, enhancing the longevity of transplanted organs.
How similar studies have gone: Previous research has shown that understanding immune responses in transplantation can lead to significant advancements in transplant success rates, indicating a promising avenue for this study.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Lakkis, Fadi G. — University of Pittsburgh at Pittsburgh
- Study coordinator: Lakkis, Fadi G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.