Understanding how the immune system affects kidney disease
ADPKD: Understanding immunosuppression mechanisms and discovering treatment
This study is looking at how the immune system interacts with kidney cells in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD) to find new ways to help keep their kidneys healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10861925 on NIH RePORTER |
What this research studies
This research investigates the role of the immune system in Autosomal Dominant Polycystic Kidney Disease (ADPKD), focusing on how certain immune cells interact with cystic kidney cells. The study examines the mechanisms by which cystic renal epithelial cells evade immune attacks, particularly through proteins like PD-1 and PD-L1. By using animal models, researchers aim to understand how targeting these proteins can influence cyst growth and kidney function. This could lead to new treatment strategies that enhance kidney health for patients with ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease.
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that slow the progression of kidney disease in patients with ADPKD.
How similar studies have performed: Previous research has shown promising results in targeting immune mechanisms in kidney diseases, suggesting potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Li, Xiaogang — Mayo Clinic Rochester
- Study coordinator: Li, Xiaogang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.