Understanding how the immune system affects HIV persistence in children
Official title: Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance
Funded at Emory University · NIH-11060875 · Data updated 2026-11-12
This study is looking at how children's immune systems affect the way HIV hides in their bodies, and it aims to find ways to help treat the virus better, so kids with HIV can live healthier lives.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,552,021 |
| NIH project number | 5P01HD112217-03 |
| Project ID | NIH-11060875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children and adolescents aged 0-20 living with HIV.
✕Less likely to help
Patients who are not living with HIV or are outside the age range of 0-20 may not benefit from this research.
What this research studies
This research investigates how the immune system in children influences the establishment and maintenance of HIV reservoirs, which are critical for viral persistence. By examining the immune responses during the perinatal period and throughout childhood, the study aims to identify factors that contribute to HIV's ability to hide in the body despite treatment. The research involves a collaborative team of scientists who will analyze immune interactions and develop targeted strategies for potential cures. Patients may be involved in providing samples and data to help understand these complex processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for curing HIV in children, significantly improving their health outcomes.
How similar studies have gone: Previous research has shown promise in understanding HIV persistence, but this approach focuses specifically on the unique immune environment of children, making it a novel investigation.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Chahroudi, Ann M — Emory University
- Study coordinator: Chahroudi, Ann M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.