Understanding how the immune system affects Candida albicans in the gut
Official title: Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut
Funded at University of Colorado Denver · NIH-11047962 · Data updated 2026-11-12
This study is looking at how your immune system affects the way a common fungus called Candida albicans can cause problems in your gut, and it aims to help us understand how to keep your gut healthy and prevent infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $78,660 |
| NIH project number | 3DP2AI177927-02S1 |
| Project ID | NIH-11047962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune deficiencies or those experiencing gastrointestinal issues related to fungal infections.
✕Less likely to help
Patients without any immune system concerns or those not affected by Candida albicans infections may not benefit from this research.
What this research studies
This research investigates how different immune environments influence the ability of the fungus Candida albicans to cause disease in the gut. By examining the role of immune factors, particularly IgA antibodies, the study aims to uncover how these immune responses can alter the pathogenic potential of C. albicans. The research will involve both laboratory experiments and analysis of immune responses in the gut, providing insights into how the immune system interacts with this common fungus. This could lead to a better understanding of gut health and infections related to C. albicans.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating infections caused by Candida albicans in patients with compromised immune systems.
How similar studies have gone: Previous research has shown that understanding the immune response to pathogens can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Ost, Kyla — University of Colorado Denver
- Study coordinator: Ost, Kyla
Related research
Other NIH-funded projects on the same topics.
-
Understanding how alcohol and how couples talk about consent affect intimate partner sexual violence
This project studies how alcohol use and how partners communicate about consent influence intimate partner sexual violence among sexual minority and heterosexual couples.
-
How proteins change and move as heart cells develop
This grant aims to map how protein turnover changes as human iPSCs turn into cardiomyocytes and other cell types, using new labeling and mass-spectrometry methods.
-
Center for Health, Work and Environment
A national center dedicated to improving health in people who work, by studying how jobs affect well-being and safety.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Expanded antibody-based clues to TB risk in people with HIV
A clinician-scientist seeks to understand how antibodies in people with HIV may drive the progression from latent TB to active TB, with the goal of identifying clues that could guide future care.
-
Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.